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Updated: Jun 10, 2026

Bilateral Common Carotid Artery Occlusion as an Adequate Preconditioning Stimulus to Induce Early Ischemic Tolerance to Focal Cerebral Ischemia
07:46

Bilateral Common Carotid Artery Occlusion as an Adequate Preconditioning Stimulus to Induce Early Ischemic Tolerance to Focal Cerebral Ischemia

Published on: May 9, 2013

[A combined method to protect the brain during operations on the brachiocephalic arteries]

V B Loenko, E A Sorokina, V E Smialovskiĭ

    Angiologiia I Sosudistaia Khirurgiia = Angiology and Vascular Surgery
    |July 20, 2010
    PubMed

    Insights

    This study shows nimodipine and rheopolyglukin effectively protect the brain during surgery for subclavian and vertebral artery atherosclerosis. Combining these with carotid artery bypass grafting during endarterectomy is also feasible and beneficial.

    Area of Science:

    • Vascular Surgery
    • Cerebrovascular Medicine
    • Neurology

    Background:

    • Atherosclerosis in carotid, subclavian, and vertebral arteries poses a risk of ischemic stroke.
    • Surgical management requires strategies to prevent cerebral ischemia.

    Purpose of the Study:

    • To evaluate a differentiated therapeutic policy for protecting the brain from ischemia during surgical management of carotid, subclavian, and vertebral artery atherosclerosis.
    • To assess the efficacy of nimodipine and rheopolyglukin for cerebral protection.
    • To determine the feasibility of combining these agents with temporary puncture carotid-artery bypass grafting during carotid endarterectomy.

    Main Methods:

    • Surgical management of 36 patients with carotid artery atherosclerosis.
    • Surgical management of 35 patients with subclavian and vertebral artery atherosclerosis.
    • Assessment of cerebral blood flow in common, internal carotid, and median cerebral arteries.

    Main Results:

    • Nimodipine and rheopolyglukin demonstrated efficiency in cerebral protection for patients undergoing operations on the subclavian and vertebral arteries.
    • Temporary puncture carotid-artery bypass grafting during carotid endarterectomy was found to be feasible and effective.
    • Puncture-mediated bypass grafting confirmed functional possibilities by studying blood flow in relevant cerebral arteries.

    Conclusions:

    • A differentiated therapeutic policy is substantiated for protecting the brain from ischemia in patients with atherosclerotic lesions of the carotid, subclavian, and vertebral arteries.
    • Nimodipine and rheopolyglukin are effective for cerebral protection in specific surgical contexts.
    • Combining pharmacological protection with minimally invasive bypass grafting offers a viable strategy for carotid endarterectomy.

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