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A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene
Published on: April 1, 2019
Methylenehydrofolate reductase (C677T) polymorphism and large artery ischemic stroke subtypes
T P They-They1, S Nadifi, M A Rafai
1Hassan II University, Ibn Rochd Hospital, District Hospitals, Casablanca, Morocco. thierrypal@yahoo.fr
Acta Neurologica Scandinavica
|July 20, 2010
Summary
The methylenetetrahydrofolate reductase (MTHFR) C677T gene variant is not linked to overall ischemic stroke risk. However, it may increase the risk of the atherothrombotic subtype in Morocco.
Area of Science:
- Genetics and Neurology
- Molecular Biology
- Epidemiology
Background:
- The association between methylenetetrahydrofolate reductase (MTHFR) C677T gene variants and ischemic stroke risk remains debated.
- Understanding genetic predispositions is crucial for stroke prevention strategies.
Purpose of the Study:
- To investigate the association between MTHFR C677T gene variants and ischemic stroke risk in a Moroccan population.
- To explore potential links between MTHFR C677T variants and specific stroke subtypes.
Main Methods:
- A case-control study was conducted in Casablanca, Morocco, involving 91 ischemic stroke cases and 182 matched controls.
- Polymerase chain reaction (PCR) followed by HinfI enzymatic digestion was used to determine allele and genotype frequencies.
Main Results:
- No statistically significant association was found between MTHFR C677T T allele carriers and overall ischemic stroke risk (OR, 1.1; 95% CI, 0.59-2.04; P = 0.303).
- A significant association was observed between T allele carriers and the atherothrombotic stroke subtype (n=42) (OR, 2.1; 95% CI, 1.17-3.8; P = 0.012).
- The TT genotype showed a significantly adjusted odds ratio of 6.5 (95% CI, 1.86-23.1; P = 0.003) for atherothrombotic stroke compared to the CC genotype.
Conclusions:
- The MTHFR C677T gene variant may be a determinant factor for atherothrombotic events in ischemic stroke patients within the Moroccan population.
- Further research is warranted to elucidate the specific mechanisms linking MTHFR C677T variants to atherothrombotic stroke.
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