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Updated: Jun 10, 2026

Detection of True IgE-expressing Mouse B Lineage Cells
Published on: December 1, 2014
Understanding the genetic regulation of IgE production
John Altin1, Chong Shen, Adrian Liston
1John Curtin School of Medical Research, Australian National University, Canberra 0200, Australia.
Abstract:
Immunoglobulin E (IgE) is a key mediator of anti-parasitic and anti-tumour immunity. However it is also a critical component of atopic and autoimmune diseases, and elevated serum IgE levels are a common indicator of immune dysregulation. In this review we survey the literature on genetic associations of elevated IgE in humans and mice. We find that defects in a limited number of pathways explain the majority of gene associations with IgE. Commonly, elevated IgE is associated with defects in Th bias and B cell class switching, severe T cell tolerance defects and defects in immunity at the host-environment interface. These genetic data demonstrate the mechanisms of control over IgE production and the manner in which they can be circumvented.
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