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Generation of Human Chimeric Antigen Receptor Regulatory T Cells
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Tissue Regulatory T Cells.

Markus Feuerer1,2, Daniel H D Gray3,4, Lucille C Rankin3,4

  • 1Research Division Immunology, Leibniz Institute for Immunotherapy, Regensburg, Germany;

Annual Review of Immunology
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Summary
This summary is machine-generated.

Tissue-resident regulatory T cells (Tregs) perform vital functions in various organs, aiding tissue repair and homeostasis. Understanding their residency program offers potential for new therapies.

Keywords:
T cellshomeostasisimmune regulationregulatory T cellstissue immunologytissue residency

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Area of Science:

  • Immunology
  • Cell Biology
  • Tissue Homeostasis

Background:

  • FOXP3+ regulatory T cells (Tregs) are known for controlling systemic immune responses.
  • A subset of Tregs resides in non-lymphoid tissues, exhibiting distinct functions beyond immune suppression.
  • These tissue-resident Tregs play crucial roles in maintaining tissue physiology, including homeostasis, repair, and regeneration.

Purpose of the Study:

  • To survey the current knowledge on the form and function of tissue-resident Tregs across multiple organs.
  • To synthesize molecular features and cellular kinetics to identify a shared program of tissue residency.
  • To review the clinical translation potential and identify knowledge gaps for therapeutic applications.

Main Methods:

  • Literature review and synthesis of existing research on tissue-resident Tregs.
  • Analysis of molecular features and cellular kinetics across different tissues.
  • Examination of Treg behavior during homeostasis and disease states.

Main Results:

  • Tissue-resident Tregs exhibit diverse beneficial roles in organs like fat, muscle, heart, brain, skin, lung, and gut.
  • A conserved molecular program drives Treg tissue residency across various tissues and species.
  • Dynamic cellular flux of tissue-resident Tregs is observed during both homeostasis and disease.

Conclusions:

  • Tissue-resident Tregs represent a distinct functional subset with significant roles in organ physiology.
  • A core residency module governs Treg adaptation to specific tissue microenvironments.
  • Further research into this population holds promise for developing novel therapeutic strategies.