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Updated: Mar 13, 2026
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Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform
Published on: August 17, 2022
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Preimplantation genetic testing: indications and controversies
Amber R Cooper1, Emily S Jungheim
1Division of Reproductive Endocrinology and Infertility, Barnes-Jewish Hospital, Washington University School of Medicine, 4444 Forest Park Parkway, St Louis, MO 63108, USA. coopera@wustl.edu
Clinics in Laboratory Medicine
|July 20, 2010
Summary
Preimplantation genetic testing has expanded for various genetic conditions, but its use involves risks and ongoing debates about accuracy and expanded applications.
Area of Science:
- Reproductive Medicine
- Human Genetics
- Clinical Embryology
Background:
- Preimplantation genetic testing (PGT) use has surged in recent decades.
- PGT identifies single-gene disorders, chromosomal abnormalities, and other genetic conditions before pregnancy.
- Advances in PGT techniques improve diagnostic accuracy but raise concerns.
Purpose of the Study:
- To review PGT techniques and clinical applications.
- To discuss the controversies and uncertainties surrounding PGT's expanded use.
- To explore the ethical considerations of genetic testing in prospective parents.
Main Methods:
- Review of current literature on PGT techniques.
- Analysis of clinical applications of preimplantation genetic diagnosis.
- Discussion of the risks, controversies, and ethical debates associated with PGT.
Main Results:
- PGT is increasingly utilized for diverse genetic screening purposes.
- Diagnostic accuracy of PGT strategies is continually improving.
- The expanded application of PGT is subject to significant debate and ethical scrutiny.
Conclusions:
- PGT offers significant advancements in reproductive genetics.
- Ongoing research and ethical discussions are crucial for responsible PGT implementation.
- Balancing technological progress with potential risks and societal implications is essential.
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