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Related Concept Videos

Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
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Preventive healthcare services keep people healthy via frequent check-ups, screening, and counseling. They primarily aid in disease prevention rather than treating an acute or chronic illness. Preventive treatment also keeps individuals productive and energetic, allowing them to work well into their retirement years. Examples of preventive care services include:

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Related Experiment Video

Updated: Jun 10, 2026

FISH for Pre-implantation Genetic Diagnosis
07:34

FISH for Pre-implantation Genetic Diagnosis

Published on: February 23, 2011

Clinical implications of first-trimester screening.

Stephen T Chasen1

  • 1Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, 525 East 68th Street, New York, NY 10065, USA. stchasen@med.cornell.edu

Clinics in Laboratory Medicine
|July 20, 2010
PubMed
Summary
This summary is machine-generated.

First-trimester aneuploidy screening offers high detection rates for Down syndrome. Early screening impacts prenatal diagnosis timing, abortion decisions, and identifies potential obstetric complications.

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Area of Science:

  • Maternal-fetal medicine
  • Prenatal diagnostics
  • Genetics

Background:

  • First-trimester aneuploidy screening is a crucial tool in prenatal care.
  • It provides high detection rates for common chromosomal abnormalities like Down syndrome.

Purpose of the Study:

  • To explore the clinical implications of early first-trimester aneuploidy screening.
  • To highlight how screening influences prenatal diagnosis and management.

Main Methods:

  • Review of clinical data and outcomes associated with first-trimester screening.
  • Analysis of the impact on invasive diagnostic procedures and gestational age.

Main Results:

  • Early screening significantly affects the timing of prenatal diagnosis and intervention.
  • It enables earlier detection of major structural abnormalities.
  • Biochemical markers, like low pregnancy-associated plasma protein A, can predict obstetric complications.

Conclusions:

  • First-trimester aneuploidy screening provides vital information for timely prenatal diagnosis and management.
  • It influences decisions regarding invasive procedures and pregnancy management, potentially improving outcomes.