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Updated: Jun 10, 2026

In Vitro Modeling of Down Syndrome Neurogenesis Using Human-Induced Pluripotent Stem Cells
06:38

In Vitro Modeling of Down Syndrome Neurogenesis Using Human-Induced Pluripotent Stem Cells

Published on: March 7, 2025

Olig1 and Olig2 triplication causes developmental brain defects in Down syndrome

Lina Chakrabarti1, Tyler K Best, Nathan P Cramer

  • 1Center for Neuroscience Research, Children's National Medical Center, Washington, DC, USA.

Nature Neuroscience
|July 20, 2010
PubMed

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During meiosis, chromosomes occasionally separate improperly. This occurs due to failure of homologous chromosome separation during meiosis I or failed sister chromatid separation during meiosis II. In some species, notably plants, nondisjunction can result in an organism with an entire additional set of chromosomes, which is called polyploidy. In humans, nondisjunction can occur during male or female gametogenesis and the resulting gametes possess one too many or one too few chromosomes.
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