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Related Concept Videos

Biofilms01:29

Biofilms

Biofilms are complex communities of microorganisms encased in a self-produced extracellular polysaccharide matrix attached to surfaces. These microbial consortia can include single or multiple species, providing enhanced survival benefits by forming organized, multilayered structures.The formation of biofilms occurs through four key stages: attachment, colonization, development, and dispersal.During attachment, free-swimming planktonic cells adhere to a surface, often facilitated by...

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Development of a Polymicrobial Colony Biofilm Model to Test Antimicrobials in Cystic Fibrosis
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Different biofilms, different disease? A clinical outcomes study.

Andrew Foreman1, Peter-John Wormald

  • 1Department of Surgery-Otorhinolaryngology, Head and Neck Surgery, University of Adelaide and Flinders University, Adelaide, Australia.

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|July 20, 2010
PubMed
Summary

Chronic rhinosinusitis (CRS) biofilms vary by species. Haemophilus influenzae biofilms correlate with mild disease, while Staphylococcus aureus biofilms indicate more severe, recalcitrant CRS requiring surgery.

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Use of a High-throughput In Vitro Microfluidic System to Develop Oral Multi-species Biofilms
07:09

Use of a High-throughput In Vitro Microfluidic System to Develop Oral Multi-species Biofilms

Published on: December 1, 2014

Area of Science:

  • Otolaryngology
  • Microbiology
  • Medical Research

Background:

  • Biofilms are implicated in Chronic Rhinosinusitis (CRS), impacting disease severity and surgical outcomes.
  • Recent advancements enable detailed characterization of CRS patient biofilms.

Purpose of the Study:

  • To investigate if distinct biofilm species within CRS are associated with different clinical outcomes.
  • To correlate specific microbial biofilm compositions with disease severity and postsurgical results.

Main Methods:

  • Retrospective review of 24 patients with medically recalcitrant CRS undergoing Endoscopic Sinus Surgery (ESS).
  • Previously characterized biofilms using fluorescence in situ hybridization (FISH).
  • Evaluated preoperative disease markers and postoperative disease recurrence (median 11 months post-surgery).

Main Results:

  • Thirty-seven biofilms were identified; nearly half were polymicrobial.
  • Polymicrobial biofilms were linked to increased preoperative disease severity but did not affect postsurgical outcomes.
  • Haemophilus influenzae biofilms were associated with mild disease and rapid mucosal healing.
  • Staphylococcus aureus biofilms correlated with more severe disease and complicated postoperative courses.

Conclusions:

  • Specific biofilm species in CRS are linked to distinct disease phenotypes.
  • Haemophilus influenzae biofilms are indicative of milder CRS.
  • Staphylococcus aureus biofilms suggest a more severe, surgically challenging disease pattern.