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Related Experiment Video

Updated: Jun 10, 2026

Humanized NOG Mice for Intravaginal HIV Exposure and Treatment of HIV Infection

Humanized NOG Mice for Intravaginal HIV Exposure and Treatment of HIV Infection

Published on: January 31, 2020

Postexposure prophylaxis against human immunodeficiency virus.

Michael A Tolle¹, Heidi L Schwarzwald

¹Baylor College of Medicine, Houston, TX 77030, USA. tolle@bcm.edu

American Family Physician

|July 21, 2010

Summary

This summary is machine-generated.

Family physicians can provide timely postexposure prophylaxis (PEP) to prevent human immunodeficiency virus (HIV) infection. Prompt initiation of a four-week, three-drug regimen is crucial for effectiveness, especially after sexual assault.

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Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors

Published on: April 9, 2014

Area of Science:

Family Medicine
Infectious Diseases
Public Health

Background:

Family physicians frequently manage potential human immunodeficiency virus (HIV) exposures.
Timely decision-making regarding postexposure prophylaxis (PEP) is critical for preventing HIV transmission.

Purpose of the Study:

To outline the indications, optimal timing, and regimens for HIV postexposure prophylaxis (PEP).
To guide family physicians in managing various HIV exposure scenarios.

Main Methods:

Review of current guidelines and evidence for HIV PEP.
Discussion of rapid HIV testing for source identification.
Description of two-drug vs. three-drug PEP regimens and their indications.

Main Results:

PEP is most effective when initiated within 72 hours and continued for four weeks.
Three-drug PEP is recommended for nonoccupational exposures, including sexual assault.
Rapid HIV testing can aid point-of-care decisions when source status is unknown.

Conclusions:

Family physicians play a key role in administering appropriate HIV PEP.
Adherence to timing and regimen guidelines maximizes PEP efficacy.
Expert consultation is advised for complex cases, such as pregnant individuals or known HIV-positive sources.