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Risk of myocardial infarction related to factor V Leiden mutation: a meta-analysis

Moataz Dowaidar1, Ahmad Settin

  • 1Genetics Unit, Egypt and Research Center, College of Medicine, Qassim University, Mansoura University Children Hospital, Buraydah, Saudi Arabia.

Genetic Testing and Molecular Biomarkers
|July 21, 2010
PubMed
Abstract

Insights

The factor V Leiden (FVL) mutation increases the risk of myocardial infarction (MI). This genetic factor is more frequent in MI patients than in healthy individuals, highlighting its clinical significance.

Area of Science:

  • Cardiovascular Genetics
  • Thrombophilia Research
  • Molecular Epidemiology

Background:

  • Myocardial infarction (MI) is linked to inherited thrombophilia, specifically resistance to activated protein C due to the factor V Leiden (FVL) mutation.
  • Understanding the prevalence and risk associated with FVL mutation in MI is crucial for cardiovascular disease research.

Purpose of the Study:

  • To determine the frequency of the FVL mutation in myocardial infarction (MI) cases across diverse populations.
  • To quantify the overall risk of MI associated with carrying the FVL mutation.

Main Methods:

  • A meta-analysis was conducted on data from 41 studies.
  • Included were 7,790 MI cases and 19,276 healthy controls.
  • Frequencies and odds ratios for FVL mutation were compared between groups.

Main Results:

  • The FVL mutation was found in 6.791% of MI cases versus 1.304% of controls.
  • An overall odds ratio of 1.608 (95% CI: 1.98-4.44) indicated a significantly increased risk of MI associated with FVL mutation.
  • Significant variations in FVL mutation frequency were observed among different populations.

Conclusions:

  • Carriage of the factor V Leiden mutation presents a definitive risk for myocardial infarction.
  • Findings have implications for genetic counseling and prophylactic strategies for families of MI patients.

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