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Novel case of generalized multinucleate cell angiohistiocytoma
Catherine A E O'Blenes1, Noreen M G Walsh, Peter J Green
1Division of Dermatology and Department of Pathology, Faculty of Medicine, Dalhousie University, Halifax, NS.
Background:
multinucleate cell angiohistiocytoma is a rare benign fibrohistiocytic and vascular proliferation, typically characterized by the development of solitary papules, in an acral distribution in otherwise healthy late middle-aged to elderly women.
Objective:
our objectives are to present a novel case of generalized multinucleate cell angiohistiocytoma and to review the current literature regarding the clinical and histologic findings in this condition, as well as its potential causes and treatments.
Observations:
we describe a 35-year-old man who presented with generalized asymptomatic firm violaceous papules. Histopathology revealed dermal vascular proliferation; a perivascular infiltrate of lymphocytes, histiocytes, neutrophils, and plasma cells; thickened surrounding collagen bundles; and characteristic multinucleate cells with scalloped borders.
Conclusion:
our patient is one of three patients reported to date with generalized lesions of multinucleate cell angiohistiocytoma who were all in a younger age group (20-40 years old) than previously reported for solitary lesions.
