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Published on: March 16, 2018
Does sodium thiosulphate delay presbyacusis?
Taeed Quddusi1, Brian W Blakley, Eric Meen
1Department of Otolaryngology-Head and Neck Surgery, University of Manitoba, Winnipeg, Manitoba. taeed@shaw.ca
Summary
Sodium thiosulphate (STS) significantly delays age-related hearing loss in mice. This study found STS improved hearing thresholds compared to normal saline over one year.
Area of Science:
- Ototoxicology
- Pharmacology
- Neuroscience
Background:
- Hearing loss is a growing concern, with age-related decline affecting many.
- Identifying effective preventative treatments for hearing loss is crucial.
Purpose of the Study:
- To investigate the efficacy of sodium thiosulphate (STS) in preventing age-related hearing loss.
- To compare STS with normal saline as a preventative measure.
Main Methods:
- A randomized animal study involving sixteen mice.
- Intraperitoneal injections of either normal saline or STS were administered.
- Auditory brainstem response testing was used to assess hearing thresholds over one year.
Main Results:
- Sodium thiosulphate (STS) treatment demonstrated a statistically significant improvement in hearing thresholds.
- Improvements in both click and pure-tone thresholds were observed compared to the saline group.
- These positive effects were sustained throughout the one-year study period.
Conclusions:
- Sodium thiosulphate (STS) shows significant potential in delaying age-associated hearing loss.
- The findings support STS as a promising therapeutic agent in a murine model.
- Further research may explore STS for human application in hearing loss prevention.
