Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Positron Emission Tomography

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Overnight sleep features and next-morning brain metabolism in older adults.

Sleep medicine·2026

Same author

SERPINE2-mediated activation of JAK2/STAT3 facilitates NRF2 nuclear translocation and GCLC transcription to confer ferroptosis resistance and lenvatinib resistance in hepatocellular carcinoma.

Journal of experimental & clinical cancer research : CR·2026

Same author

Tumor microenvironment-driven mechanisms of photodynamic therapy resistance and emerging targeted combination strategies.

Journal of photochemistry and photobiology. B, Biology·2026

Same author

Identification of a Prognostic Gene Signature Based on Lenvatinib Resistance in Hepatocellular Carcinoma with Functional Validation of the Key Gene CPB2.

Journal of hepatocellular carcinoma·2026

Same author

A synergistic dual-endopeptidase platform for high-yield, homogeneous F(ab')<sub>2</sub> production from polyclonal equine immunoglobulins for therapeutic applications.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences·2026

Same author

Clinician engagement shapes the impact of AI-based ECG screening for chronic liver disease in primary care.

NPJ digital medicine·2026

Same journal

Increased Brownian Motion of Water Molecules in Livers With Advanced Fibrosis: Preclinical and Clinical Observations With Magnetic Resonance Imaging (MRI).

Molecular imaging·2026

Same journal

Carrier-Free Ce6&SR717 Nanomedicine Enables Abscopal Photoimmunotherapy via cGAS-STING Activation in Breast Cancer.

Molecular imaging·2026

Same journal

Radiomic Analysis of MRI for Assessing Response to Neoadjuvant Chemoradiotherapy in Rectal Adenocarcinoma: A Systematic Review and Metaanalysis.

Molecular imaging·2026

Same journal

Self-Supervised Learning Method for 3D Detection of Lung Cancer Based on PET Imaging.

Molecular imaging·2026

Same journal

Low-Dose <sup>125</sup>I-Irradiation Enhances PRC1-Targeted NIS-CAR-T Cell Cytotoxicity Against Breast Cancer Cells.

Molecular imaging·2026

Same journal

Corrigendum to "Positron Emission Tomography (PET) with <sup>18</sup>F-FGA for Diagnosis of Myocardial Infarction in a Coronary Artery Ligation Model".

Molecular imaging·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 10, 2026

The Microfluidic Probe: Operation and Use for Localized Surface Processing

The Microfluidic Probe: Operation and Use for Localized Surface Processing

Published on: June 4, 2009

Microfluidics for positron emission tomography probe development.

Ming-Wei Wang¹, Wei-Yu Lin, Kan Liu

¹Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.

Molecular Imaging

|July 21, 2010

Summary

This summary is machine-generated.

Microfluidic reactors offer advantages for positron emission tomography (PET) probe production, enabling faster reactions and higher yields. This technology supports a decentralized model for radiotracer distribution, making molecular imaging more accessible.

More Related Videos

Fast Enzymatic Processing of Proteins for MS Detection with a Flow-through Microreactor

Fast Enzymatic Processing of Proteins for MS Detection with a Flow-through Microreactor

Published on: April 6, 2016

High Throughput Microfluidic Rapid and Low Cost Prototyping Packaging Methods

High Throughput Microfluidic Rapid and Low Cost Prototyping Packaging Methods

Published on: December 23, 2013

Related Experiment Videos

Last Updated: Jun 10, 2026

The Microfluidic Probe: Operation and Use for Localized Surface Processing

The Microfluidic Probe: Operation and Use for Localized Surface Processing

Published on: June 4, 2009

Fast Enzymatic Processing of Proteins for MS Detection with a Flow-through Microreactor

Fast Enzymatic Processing of Proteins for MS Detection with a Flow-through Microreactor

Published on: April 6, 2016

High Throughput Microfluidic Rapid and Low Cost Prototyping Packaging Methods

High Throughput Microfluidic Rapid and Low Cost Prototyping Packaging Methods

Published on: December 23, 2013

Area of Science:

Radiochemistry
Medical Imaging
Chemical Engineering

Background:

Increasing demand for positron emission tomography (PET) necessitates advancements in radiolabeled compound production.
Conventional radiolabeling systems face challenges in efficiency and precursor utilization.

Purpose of the Study:

To explore the application of microfluidic reactors in radiosynthesis for PET probe development.
To highlight the advantages of microfluidics over traditional radiolabeling methods.

Main Methods:

Review of microfluidic reactor designs for radiosynthesis.
Discussion of device architecture, operation, and limitations.
Exploration of a decentralized model for radioisotope distribution.

Main Results:

Microfluidics enables reduced precursor use, faster reaction kinetics, and simplified purification.
Potential for higher yields and specific activity of PET probes.
Demonstration of proof-of-principle examples for microfluidic radiosynthesis.

Conclusions:

Microfluidic radiochemistry offers significant advantages for PET probe production.
Automated, flexible microfluidic platforms can simplify and reduce costs for molecular imaging.
This technology supports a decentralized model for radioisotope supply.