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Updated: Jun 10, 2026

Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation
Published on: February 10, 2023
Increased sequence conservation of domain repeats in prokaryotic proteins
Dan Reshef1, Zohar Itzhaki, Ora Schueler-Furman
1Department of Microbiology and Molecular Genetics, Institute for Medical Research Israel-Canada, Hadassah Medical School, The Hebrew University of Jerusalem, Israel.
Abstract:
Protein domain repeats within a protein sequence have been observed throughout all domains of life. Our analysis shows a significantly higher degree of sequence identity between repeated domains in prokaryotes compared to eukaryotes. We discuss this difference in the light of aggregation prevention, contribution to functional divergence and binding-related functions. We then address the possible underlying features that create and conserve domain repeats. Our findings provide a starting point for the identification of the fundamental principles that underlie this basic difference between eukaryotic and prokaryotic protein evolution.
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