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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
Drug Delivery Systems: Different Types01:27

Drug Delivery Systems: Different Types

Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...
Oral Drug Delivery Systems: Delayed-Release Systems01:11

Oral Drug Delivery Systems: Delayed-Release Systems

Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...
Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
Modified-Release Drug Delivery Systems: Overview01:19

Modified-Release Drug Delivery Systems: Overview

Modified-release dosage forms are designed to address the limitations of drugs with short biological half-lives. These forms maintain stable therapeutic drug concentrations over extended periods, reducing the need for frequent dosing. A consistent drug level helps minimize peak-trough fluctuations, which can reduce adverse effects, lower the risk of drug resistance, and improve overall treatment effectiveness.One common type of modified-release form is the extended-release (ER) formulation. ER...

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Related Experiment Video

Updated: Jun 10, 2026

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
07:32

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Published on: August 28, 2015

Polymeric multilayer capsules in drug delivery.

Liesbeth J De Cock1, Stefaan De Koker, Bruno G De Geest

  • 1Laboratory of Pharmaceutical Technology, Department of Pharmaceutics, Ghent University, Harelbekestraat 72, 9000 Ghent, Belgium.

Angewandte Chemie (International Ed. in English)
|July 21, 2010
PubMed
Summary

Intelligent nanoengineered delivery systems, like polymeric multilayer capsules, offer precise therapeutic release. These advanced systems provide enhanced control for novel drug delivery applications.

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Area of Science:

  • Biotechnology and Nanomedicine
  • Materials Science

Background:

  • Advances in medicine necessitate sophisticated nanoengineered delivery systems for diverse therapeutics like proteins, chemotherapeutics, and nucleic acids.
  • Intelligent delivery systems are crucial for timed, targeted, or stimulus-responsive drug release.
  • Polymeric multilayer capsules, fabricated via layer-by-layer (LbL) assembly, offer precise control over microcapsule functionality.

Purpose of the Study:

  • To provide an overview of recent breakthroughs in the application of polymeric multilayer capsules for drug delivery.
  • To highlight the design flexibility and functional control offered by LbL assembly for nanoengineered systems.

Main Methods:

  • Layer-by-layer (LbL) coating of a sacrificial template.
  • Dissolution of the sacrificial template to yield polymeric multilayer capsules.
  • Assembly in aqueous conditions using simple building blocks and procedures.

Main Results:

  • Polymeric multilayer capsules enable the design of microcapsules with precise control over functionality.
  • Recent systems incorporate biodegradable components and biospecific functionalities.
  • These capsules demonstrate significant potential for advanced drug delivery applications.

Conclusions:

  • Polymeric multilayer capsules represent a versatile platform for developing intelligent drug delivery systems.
  • The LbL assembly method provides unprecedented control for tailoring capsule properties.
  • These nanoengineered systems are gaining traction in the life sciences for therapeutic applications.