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New macrolide, lincosaminide and streptogramin B antibiotics
1Eli Lilly and Company, 7840 West 88th Street, Indianapolis, IN 46278, USA. herbertkirst1@comcast.net
Importance Of The Field:
New antibiotics are needed to overcome microbial resistance and to improve on the therapeutic index and clinical effectiveness of existing agents.
Area Covered In This Review:
This review covers the journal and patent literature published from about the mid-2000s to 2010 to provide an overview of the large diversity of new chemical entities in the macrolide, lincosaminide and streptogramin B (MLS(B)) class.
What The Reader Will Gain:
The review identifies areas of the greatest effort and recent results in pursuing structure-activity relationships among MLS(B) antibiotics and highlights preclinical and clinical candidates that have arisen from these diverse discovery programs.
Take Home Message:
Research on the MLS(B) class appears promising for the eventual registration and commercialization of several new antibiotics that improve the clinical effectiveness of existing agents and combat antibiotic-resistant pathogens.
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