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Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas

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Published on: January 26, 2024

Pre-eclampsia: connecting angiogenic and metabolic pathways.

Vivek Shenoy¹, Keizo Kanasaki, Raghu Kalluri

¹Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.

Trends in Endocrinology and Metabolism: TEM

|July 22, 2010

Summary

This review explores pre-eclampsia, a pregnancy hypertension affecting 5-8% globally. Research links it to angiogenic imbalance and metabolic dysfunction, particularly homocysteine and placental glycogen metabolism.

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Area of Science:

Obstetrics and Gynecology
Cardiovascular Research
Metabolic Disorders

Background:

Pre-eclampsia is a significant hypertensive disorder in pregnancy, affecting 5-8% worldwide.
Current understanding of pre-eclampsia pathogenesis is incomplete.
Recent research highlights potential links between angiogenic and metabolic pathways.

Purpose of the Study:

To review recent advancements in pre-eclampsia research.
To explore the roles of angiogenesis and metabolism in pre-eclampsia development.
To update existing models of pre-eclampsia pathogenesis.

Main Methods:

Literature review focusing on angiogenesis and metabolism in pre-eclampsia.
Analysis of the 'angiogenic imbalance' theory involving factors like sFlt1, 2-ME, and COMT.
Examination of the association between pre-eclampsia and homocysteine/placental glycogen metabolism.

Main Results:

The 'angiogenic imbalance' theory suggests pre-eclampsia arises from dysregulated angiogenesis.
Specific factors implicated include soluble fms-like tyrosine kinase (sFlt1), 2-methoxyestradiol (2-ME), and catechol-O-methyltransferase (COMT).
Dysfunctional metabolism of homocysteine and placental glycogen is associated with pre-eclampsia.

Conclusions:

Angiogenesis and metabolism are interconnected in pre-eclampsia pathogenesis.
Understanding these links can refine existing models of the disease.
Further research into these pathways may reveal new therapeutic targets.