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Updated: Jun 10, 2026
05:53
Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
Published on: June 21, 2018
Pharmacogenetics of asthma.
Rodolfo M Pascual1, Eugene R Bleecker
1Wake Forest University Health Sciences, Center for Genomics and Personalized Medicine Research, Medical Center Boulevard, Winston-Salem, NC 27157, United States.
Current Opinion in Pharmacology
|July 22, 2010
Summary
Asthma
Area of Science:
- Pulmonary Medicine
- Genetics
- Pharmacology
Background:
- Asthma is a complex genetic disease influenced by gene-environment interactions.
- Patient heterogeneity in clinical and inflammatory phenotypes affects treatment response.
- Current asthma therapies show variable efficacy and safety across patient populations.
Purpose of the Study:
- To explore the role of pharmacogenetics in understanding asthma heterogeneity.
- To identify how genetic variations influence patient response to asthma treatments.
- To highlight the potential of personalized medicine for difficult-to-treat asthma.
Main Methods:
- Review of current literature on asthma genetics and treatment responses.
- Analysis of pharmacogenetic interactions affecting corticosteroid efficacy.
- Discussion of biologic therapy outcomes in diverse asthma phenotypes.
Main Results:
- Genetic factors and environmental influences contribute to asthma severity and heterogeneity.
- Pharmacogenetic interactions can lead to reduced responsiveness to standard asthma therapies.
- Variable results in clinical trials for biologics may stem from patient heterogeneity.
Conclusions:
- Pharmacogenetics offers a promising approach to personalize asthma treatment.
- Tailoring therapies based on individual genotypes can improve outcomes and minimize side effects.
- Personalized medicine strategies are crucial for managing severe or difficult-to-treat asthma.
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