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Updated: Jun 10, 2026
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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
Managing antimicrobial resistance in intensive care units
Tejal N Gandhi1, Daryl D DePestel, Curtis D Collins
1Department of Internal Medicine, Division of Infectious Diseases, University of Michigan, Ann Arbor, MI, USA. tgandhi@med.umich.edu
Critical Care Medicine
|July 22, 2010
Summary
Intensive care unit clinicians face challenges with multidrug-resistant infections due to limited antimicrobial options. Antimicrobial stewardship programs help balance effective treatment and judicious use to combat resistance and improve patient outcomes.
Area of Science:
- Infectious Diseases
- Critical Care Medicine
- Pharmacology
Background:
- Managing infections in intensive care units (ICUs) is increasingly difficult due to rising multidrug-resistant pathogens.
- Limited antimicrobial choices necessitate careful treatment strategies for ICU patients.
Purpose of the Study:
- To explore strategies for balancing effective antimicrobial therapy with judicious antimicrobial utilization in the ICU.
- To highlight the role of antimicrobial stewardship programs in improving patient outcomes and reducing resistance.
Main Methods:
- Review of current challenges in antimicrobial management for ICU infections.
- Discussion of strategies for optimizing antimicrobial use.
- Emphasis on the implementation of antimicrobial stewardship programs.
Main Results:
- Effective antimicrobial therapy and improved utilization are achievable simultaneously.
- Antimicrobial stewardship programs offer a structured approach to these strategies.
- These programs enhance physician success in combating antimicrobial resistance.
Conclusions:
- Antimicrobial stewardship is crucial for managing infections in the ICU.
- Optimizing antimicrobial use is key to reducing resistance.
- Stewardship programs improve patient outcomes and combat antimicrobial resistance in ICUs.
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