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Working memory refers to a combination of components, including short-term memory and attention, that allow an individual to hold information temporarily as we perform cognitive tasks. It is an essential cognitive function that enables the execution of complex tasks such as problem-solving, comprehension, and reasoning. Unlike short-term memory, which simply involves the storage of information for a brief period, working memory involves the active manipulation and processing of this information.
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Related Experiment Video

Updated: Jun 10, 2026

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
10:43

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Published on: July 1, 2014

Default network connectivity during a working memory task.

Robyn L Bluhm1, C Richard Clark, Alexander C McFarlane

  • 1Department of Philosophy and Religious Studies, Old Dominion University, Norfolk, Virginia, USA.

Human Brain Mapping
|July 22, 2010
PubMed
Summary
This summary is machine-generated.

This study reveals how brain connectivity changes during cognitive tasks. Default network regions like the posterior cingulate cortex (PCC) and medial prefrontal cortex (mPFC) connect differently with other brain areas during working memory tasks.

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Related Experiment Videos

Last Updated: Jun 10, 2026

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Combining Transcranial Magnetic Stimulation and fMRI to Examine the Default Mode Network
11:02

Combining Transcranial Magnetic Stimulation and fMRI to Examine the Default Mode Network

Published on: December 28, 2010

Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Brain Imaging

Background:

  • The default network shows correlated activity at rest.
  • Default network activation decreases during cognitive tasks.
  • Task-related changes in default network connectivity remain under-investigated.

Purpose of the Study:

  • To investigate task-related modulation of default network connectivity.
  • To compare default network connectivity during rest versus a working memory task.
  • To identify changes in connectivity between default network nodes (PCC, mPFC) and other brain regions.

Main Methods:

  • Examined task-related modulation of connectivity in 12 healthy adults.
  • Focused on seed regions: posterior cingulate cortex (PCC) and medial prefrontal cortex (mPFC).
  • Compared connectivity during resting state versus a working memory task.

Main Results:

  • Little change in connectivity within the default network was observed.
  • Moderate task-related changes occurred between default network seeds and regions outside the default network.
  • Specific increases in connectivity were noted between PCC/mPFC and regions implicated in working memory, such as the inferior frontal gyri and cerebellum.

Conclusions:

  • Default network connectivity is modulated during cognitive tasks, particularly working memory.
  • Task performance involves altered connectivity patterns between default network regions and task-positive networks.
  • These findings suggest a shift in functional brain organization during cognitive engagement.