Neurosteroid transport by the organic solute transporter OSTα-OSTβ

Fang Fang1, Whitney V Christian, Sadie G Gorman

  • 1Department of Environmental Medicine, University of Rochester School of Medicine, Rochester, New York 14642, USA.

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Transcellular Transport of Solutes

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Drug Absorption Mechanism: Carrier-Mediated Membrane Transport

Certain large, lipid-insoluble drug molecules that resemble amino acids, peptides, or glucose, require specialized carrier proteins to facilitate their diffusion across cell membranes. This transport can occur through either facilitated diffusion, which does not require energy input, or active transport, which does require energy input.
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Membrane Asymmetry Regulating Transporters

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Flippase
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The plasma membrane, a critical structure in cellular biology, houses an array of transporters, or carrier proteins, interspersed within its lipid bilayer. These proteins play a crucial role in solute transport through facilitated diffusion, a form of passive diffusion that uses transporters to move the molecules across the membrane.
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