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Updated: Jun 10, 2026

Detection of MicroRNA Expression in the Kidneys of Immunoglobulin A Nephropathic Mice
Published on: July 8, 2020
Immunoglobulin A1 protease: a new therapeutic candidate for immunoglobulin A nephropathy
Lin-Shen Xie1, Jun Huang, Wei Qin
1Department of Nephrology, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Abstract:
Immunoglobulin A nephropathy (IgAN), characterized by predominant or exclusive deposition of IgA1 in glomerular mesangium, is the most common primary glomerulonephritis worldwide. At present, the treatment is always limited due to the incomplete understanding of the pathogenesis of IgAN. Mesangial deposited IgA1 is the common final pathway leading to glomerulonephritis and renal injury. IgA1 protease, a proteolytic enzyme with strict substrate specificity for human IgA1, may be an effective therapeutic candidate for IgAN by removing the mesangial deposited IgA1.
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