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Targeting the dynamic HSP90 complex in cancer

Jane Trepel1, Mehdi Mollapour, Giuseppe Giaccone

  • 1Medical Oncology Branch Center for Cancer Research, National Cancer Institute, Building 10, room 1-5940, 9000 Rockville Pike, Bethesda, MD 20892, USA.

Nature Reviews. Cancer
|July 24, 2010
PubMed

Insights

Cancer cells rely on heat shock protein 90 (HSP90) to support oncoprotein function. Understanding HSP90

Area of Science:

  • Molecular biology
  • Oncology
  • Biochemistry

Background:

  • Heat shock protein 90 (HSP90) is a molecular chaperone crucial for cancer cell survival.
  • Cancer cells exhibit a dependency, or 'addiction,' to HSP90 for the function of numerous oncoproteins.

Purpose of the Study:

  • To explore the complex role of HSP90 in cancer.
  • To investigate the implications of HSP90 regulation for targeted cancer therapeutics.

Main Methods:

  • Analysis of HSP90's role in neoplastic cellular physiology.
  • Evaluation of HSP90's involvement in normal cellular functions.

Main Results:

  • HSP90 facilitates the function of multiple oncoproteins in cancer cells.
  • HSP90 plays a role in both cancer and normal cellular physiology.

Conclusions:

  • Optimal use of HSP90 inhibitors requires a deep understanding of HSP90's complex regulatory network.
  • Further research into HSP90's dual role is essential for developing effective HSP90-targeted cancer therapies.

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