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New antibiotic structures from fermentations.

Sheo B Singh1, Katherine Young

  • 1Merck Research Laboratories, xDPS, 126 E. Lincoln Ave., RY33-612, Rahway, NJ 07065, USA. sheo_singh@merck.com

Expert Opinion on Therapeutic Patents
|July 27, 2010
PubMed
Summary
This summary is machine-generated.

Natural products from fermentation remain crucial for discovering new antibiotics, despite diminishing returns. A review of 2005-2009 patent literature highlights 44 novel structures, emphasizing the need for continued natural product research to combat antibiotic resistance.

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Area of Science:

  • Microbiology
  • Medicinal Chemistry
  • Drug Discovery

Background:

  • Fermentation-derived natural products have historically been a primary source of antibiotics.
  • While many established antibiotics originate from natural products, their discovery rate has slowed.
  • Recent approvals include novel antibiotic classes, with daptomycin being a notable natural product example.

Purpose of the Study:

  • To survey patent literature for antibiotics discovered via fermentation between 2005 and 2009.
  • To provide an overview of newly identified antibiotic structures and their sources.
  • To assess the ongoing contribution of natural products to antibiotic discovery.

Main Methods:

  • Comprehensive review of patent literature from 2005-2009.
  • Inclusion of supporting data from scientific literature.
  • Analysis of reported antibiotic structures and their originating organizations.

Main Results:

  • Identification of 44 novel antibiotic structures reported within the 5-year period.
  • Discovery of significant new compounds including platensimycin, platencin, and amycolamicin.
  • Documentation of various thiazolyl peptides as newly discovered antibiotic entities.

Conclusions:

  • Natural products continue to be a vital resource for novel antibiotic discovery.
  • A renewed focus on natural product research is essential for developing new antibiotics.
  • Continued investigation is critical to address the challenge of drug-resistant bacteria.