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Related Concept Videos

Drug Accumulation During Multiple Dosing: Repetitive IV Injections01:21

Drug Accumulation During Multiple Dosing: Repetitive IV Injections

Calculating drug dosage and accumulation in multiple-dose regimens is crucial for achieving therapeutic efficacy while avoiding toxicity. This involves determining the plasma drug concentrations over time to optimize dosing schedules. The principle of superposition is fundamental in this process, allowing for the prediction of drug concentration in plasma following multiple doses based on single-dose data.The principle of superposition asserts that the plasma concentration-time curves from...
Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
Specialized Care Centers and Settings-II01:30

Specialized Care Centers and Settings-II

Rural Health Centers
Rural health centers are specialized care facilities in remote locations with very few medical personnel. The primary care providers who run the centers are mostly Registered Nurse Practitioners. Here, emergency treatment is provided to critically ill or injured patients before they are transferred to the closest hospital. Fortunately, due to advancement in technology, many rural healthcare facilities and professionals have easy access to diagnostic and treatment...
Drug Accumulation During Multiple Dosing: Intermittent IV Infusions01:24

Drug Accumulation During Multiple Dosing: Intermittent IV Infusions

Intermittent intravenous (IV) infusion is a method of drug administration where medications are delivered over short infusion periods followed by intervals of no drug delivery. This approach helps to prevent sustained high drug concentrations in the bloodstream, reducing the risk of adverse effects associated with prolonged exposure. Unlike continuous infusion, steady-state concentrations may not be achieved during a single dosing cycle but can be reached through repeated...
Restorative Care01:19

Restorative Care

Restorative care is provided once a patient has been discharged from a healthcare facility and requires additional services. The additional services include home care, rehabilitation programs, and extended care. Restorative care centers help the patient regain their previous level of functioning or acquire a new level of functioning due to the incapacitating effects of a disease or a disability. It aims to assist patients in enhancing their quality of life by encouraging independence,...
Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy01:26

Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy

Continuous Renal Replacement Therapy (CRRT) is an essential intervention for patients experiencing severe kidney dysfunction. This therapy offers a continuous mechanism for removing fluids and toxins from the bloodstream, leveraging the patient’s blood pressure to facilitate filtration through a specialized filter. This method contrasts with intermittent dialysis, providing a gentler and more consistent removal of waste products and excess fluid, which is particularly beneficial in critically...

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Related Experiment Video

Updated: Jun 10, 2026

A Procedure to Study Stress-Induced Relapse of Heroin Seeking after Punishment-Imposed Abstinence
08:05

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Published on: March 23, 2022

Is Vancouver Canada's supervised injection facility cost-saving?

Steven D Pinkerton1

  • 1Center for AIDS Intervention Research, Department of Psychiatry and Behavioral Medicine, Medical College of Wisconsin, 2071 North Summit Avenue, Milwaukee, WI 53202, USA. pinkrton@mcw.edu

Addiction (Abingdon, England)
|July 27, 2010
PubMed
Summary

Vancouver's Insite supervised injection facility and syringe exchange programs are cost-saving. The savings from averted HIV medical costs significantly exceed the facility's operating expenses, demonstrating its economic value.

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Area of Science:

  • Public Health
  • Health Economics
  • Infectious Disease Prevention

Background:

  • Vancouver's Insite facility provides supervised injection and syringe exchange services.
  • The economic impact of these harm reduction programs requires evaluation.

Purpose of the Study:

  • To assess if Insite's programs are cost-saving.
  • To determine if averted HIV medical costs offset operational expenses.

Main Methods:

  • Mathematical modeling to estimate HIV infections if Insite closed.
  • Comparison of lifetime HIV medical costs for new infections versus Insite's operating costs.

Main Results:

  • Closing Insite would increase annual HIV infections among Vancouver IDUs by 83.5.
  • These infections represent $17.6 million in lifetime HIV medical costs.
  • Insite's annual operating costs are approximately $3 million.

Conclusions:

  • Insite's programs significantly reduce HIV incidence in the IDU community.
  • Averted HIV medical care costs substantially exceed Insite's operating costs.
  • The facility is a cost-saving public health intervention.