[Flow cytome tric analysis of cellular DNA content and cytokinetic study of experimental lung squamous cell carcinoma...

Cellular DNA content in normal lung tissues (group 1, 7 wistar rats), in tissues adjacent to lung cancers (group 2, 8 rats) and in experimental lung squamous cell carcinomas (group 3, 10 rats) was measured by flow cytometry. The results were as follows. Of 10 experimental lung cancers, 8 had aneuploid DNA content, 1 had multiple aneuploid stem lines, and 1 had diploid DNA content. But DNA content in normal lung tissues and in tissues adjacent to experimental lung cancers was all diploidy. Concerning the number of S phase cell and proliferative index, there was significant difference between group 1 and 2 as well as between group 3 and either group 1 or 2.