Related Experiment Video
Updated: Jun 10, 2026

The Lambda Select cII Mutation Detection System
Published on: April 26, 2018
Lack of Mutagenicity of Polycyclic Musk Fragrances in Salmonella typhimurium
V Mersch-Sundermann1, S Kevekordes, C Jenter
1Institute of Medical Microbiology and Hygiene, Faculty of Clinical Medicine Mannheim, University of Heidelberg, D-68135, Mannheim, Germany.
Abstract:
Synthetic musks are widely used as fragrances and therefore found in various environmental samples. Residues were identified in river and waste water, animal and human tissues and breast milk. In the present study, six artificial polycyclic musk fragrances-Galaxolide, Tonalide, Celestolide, Phantolide, Cashmeran and Traseolide-were tested for mutagenicity using the Salmonella/mammalian-microsome assay with Salmonella typhimurium strains TA97, TA98, TA100 and TA102 in the presence (+S-9) and absence (-S-9) of an exogenous metabolizing system. All compounds tested exhibited no mutagenicity in the Salmonella assay. These results could be rated as one indicator of the biological inactivity of this group of chemicals with respect to genotoxicity.
Related Concept Videos
Mutagenicity and Carcinogenicity
Mismatch Repair
Mismatch Repair
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
Spontaneous and Induced Mutations

