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Related Experiment Video

Updated: Jun 10, 2026

Eye Irritation Test (EIT) for Hazard Identification of Eye Irritating Chemicals using Reconstructed Human Cornea-like Epithelial (RhCE) Tissue Model

Eye Irritation Test (EIT) for Hazard Identification of Eye Irritating Chemicals using Reconstructed Human Cornea-like Epithelial (RhCE) Tissue Model

Published on: August 23, 2015

Eye irritation: updated reference chemicals data bank.

D M Bagley¹, J R Gardner, G Holland

¹Colgate-Palmolive Co., 909 River Road, PO Box 1343, Piscataway, NJ 08855-1343, USA.

Toxicology in Vitro : an International Journal Published in Association with BIBRA

|July 27, 2010

Summary

A comprehensive database now includes 132 chemicals with rabbit eye irritation data, crucial for validating alternatives to animal testing. This resource aids in developing safer, non-animal testing methods for chemical safety assessments.

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Area of Science:

Toxicology
Chemical Safety Assessment

Background:

An expanded dataset of 132 chemicals with rabbit eye irritation data is now available, building upon a previous 1992 ECETOC publication.
This data bank comprises results from 149 in vivo studies conducted since 1981, adhering to OECD Test Guideline 405 and Good Laboratory Practice principles.

Purpose of the Study:

To provide an updated and enlarged reference data bank of rabbit eye irritation test results.
To support the validation of alternative methods for assessing chemical eye irritation potential, reducing reliance on animal testing.

Main Methods:

Data compilation from existing in vivo rabbit eye irritation studies (OECD TG 405).
Chemicals were tested as solids or aqueous solutions, with data evaluated based on a 'modified maximum average score'.
Studies involved at least three rabbits, with observations recorded at 1, 2, and 3 days post-instillation.

Main Results:

The data bank now contains information on 132 chemicals, with 77 added since the initial 1992 publication.
Chemicals included are of high purity, stable, and tested according to standardized protocols.

Conclusions:

The enlarged reference data bank is a valuable resource for the validation of alternative methods to the in vivo rabbit eye irritation test.
This resource supports the development and regulatory acceptance of non-animal testing strategies for eye irritation.