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Safety profile of Colgate Platinum Professional Toothwhitening System
Compendium (Newtown, Pa.)
|September 28, 2018
Summary
Colgate Platinum, a tooth-whitening paste, showed no acute oral toxicity or mutagenic effects in rat studies. Repeated application did not cause oral irritation, confirming its safety for intended use.
Area of Science:
- Oral hygiene product safety evaluation
- Toxicology and genotoxicity testing
- Dermatology and mucosal irritation studies
Background:
- Professional tooth-whitening products require rigorous safety assessments.
- Urea peroxide is a common active ingredient in dental bleaching agents.
- Understanding potential risks associated with cosmetic dental treatments is crucial.
Purpose of the Study:
- To evaluate the safety profile of Colgate Platinum, a professional tooth-whitening paste.
- To assess acute oral toxicity, genotoxicity, and oral mucosal irritation potential.
- To provide data supporting the safe use of the product.
Main Methods:
- Acute oral toxicity was assessed via single oral dose administration in rats.
- Genotoxicity was evaluated using the Ames/Salmonella Plate Incorporation assay and in vivo bone marrow assays.
- Oral mucosal irritation was studied in rats following repeated topical application for 28 days.
Main Results:
- A single oral dose of 5 g/kg did not result in adverse effects.
- Colgate Platinum demonstrated no mutagenic potential in the Ames test.
- No primary DNA damage was observed in bone marrow cells, and no oral tissue damage occurred after repeated application.
Conclusions:
- Colgate Platinum is safe for its intended use as a professional tooth-whitening paste.
- The product exhibits a favorable safety profile regarding toxicity and irritation.
- Comprehensive safety data supports the use of urea peroxide-based whitening agents.
Keywords:
AnimalBone Marrow/DRUG EFFECTSDrug CombinationsFemaleMaleMouth Mucosa/DRUG EFFECTSMutagenicity TestsPeroxides/*TOXICITYRatsRats, Sprague-DawleySalmonella typhimurium/DRUG EFFECTSSister Chromatid ExchangeTooth Bleaching/*METHODSTooth Bleaching/ADVERSE EFFECTSUrea/*ANALOGS & DERIVATIVESUrea/*TOXICITY
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