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Related Experiment Videos

Reversion of the steroid-induced decrease of serum osteocalcin with sodium fluoride.

H Rico1, J A Cabranes, E R Hernandez

  • 1Department of Medicine, University of Alcala de Henares, Madrid, Spain.

Clinical Rheumatology
|March 1, 1991
PubMed
Summary
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Sodium fluoride and vitamin D can increase osteocalcin levels in patients undergoing corticoid therapy. Sodium fluoride appears more effective than vitamin D in treating steroid-induced osteopenia.

Area of Science:

  • Endocrinology
  • Bone Metabolism
  • Pharmacology

Background:

  • Corticotherapy can lead to osteopenia, characterized by decreased bone formation indicated by reduced osteocalcin levels.
  • Current treatments for steroid-induced osteopenia lack consensus on the most effective approach.
  • Sodium fluoride and vitamin D are known to elevate osteocalcin levels.

Purpose of the Study:

  • To compare the efficacy of sodium fluoride versus vitamin D in treating steroid-induced osteopenia.
  • To assess the impact of sodium fluoride and vitamin D on osteocalcin levels in patients on corticoid therapy.

Main Methods:

  • Two groups of patients on corticoid therapy were treated with either sodium fluoride (50 mg/day) or 1 alpha (OH)2D3 (0.5 micrograms/day).
  • Osteocalcin levels were measured before and after treatment in both groups.

Related Experiment Videos

  • Treated groups were compared with respective control groups.

    • Main Results:

    • Both sodium fluoride and vitamin D treatments led to significant increases in osteocalcin levels.
    • Sodium fluoride treatment showed a higher level of significance (p < 0.001) in increasing osteocalcin compared to vitamin D (p < 0.01).
    • Control groups also exhibited a significant increase in osteocalcin levels (p < 0.001).

    Conclusions:

    • Sodium fluoride may be a more effective treatment option than vitamin D for managing steroid-induced osteopenia.
    • Further research is warranted to confirm the superior efficacy of sodium fluoride in this patient population.