Related Experiment Video
Updated: Jun 10, 2026

Protocol for Plasmodium falciparum Infections in Mosquitoes and Infection Phenotype Determination
Published on: July 4, 2007
Plasmodium vivax and the Duffy antigen: a paradigm revisited
O Mercereau-Puijalon1, D Ménard
1Institut Pasteur, unité d'immunologie moléculaire des parasites, 28, rue du Dr-Roux, 75724 Paris cedex 15, France. odile.puijalon@pasteur.fr
Abstract:
The Duffy blood group antigen is the portal of entry of the Plasmodiumvivax malaria parasite into human red blood cells and the receptor for a number of CXC and CC chemokines. We review here epidemiological data and evidence derived from therapeutic or experimental human infections associating P. vivax and the Duffy glycoprotein and laboratory studies indicating that P. vivax uses the Duffy antigen as a receptor to invade the red cell. We then review recent field observations indicating that the conclusion of the absolute dependence on the presence of Duffy on the red cell for P. vivax infection and development into the red cell no longer holds true and that in some parts of the world, P. vivax infects and causes disease in Duffy-negative people.
More Related Videos
07:04Detection of Plasmodium Sporozoites in Anopheles Mosquitoes using an Enzyme-linked Immunosorbent Assay
Published on: September 30, 2021
08:46Myeloid Cell Isolation from Mouse Skin and Draining Lymph Node Following Intradermal Immunization with Live Attenuated Plasmodium Sporozoites
Published on: May 18, 2016
Related Concept Videos
Malaria
Diversity of Protists II
Symbiosis
Diversity of Protists IV
Toxoplasmosis
Diversity of Protists I