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Updated: Aug 14, 2026
Recording and Modulation of Epileptiform Activity in Rodent Brain Slices Coupled to Microelectrode Arrays
Published on: May 15, 2018
Changes in seizure activity of the neocortex during the early postnatal development of the rat: an
I Világi1, I Tarnawa, I Banczerowski-Pelyhe
1Department of Comparative Physiology, Eötvös Loránd University, Budapest, Hungary.
Abstract:
NMDA receptor-mediated process of rat neocortex slices prepared from 2-24-day-old rats were studied in Mg(2+)-free solution. The response to NMDA application as well as the susceptibility to epileptiform discharges showed age-dependent changes during the first 4 weeks. Slices from the youngest age group seemed to be the most sensitive to NMDA, whereas epileptic activity developed most readily at around the third week.
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