Related Experiment Video
Updated: Jun 10, 2026
08:56
Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue
Published on: May 17, 2018
Peripheral fatigue: high-energy phosphates and hydrogen ions
1Center for the Study of Chronic Illness and Disability, Department of Global and Community Health, College of Health and Human Services, George Mason University, 4400 University Drive, Fairfax, VA 22030, USA. rkeyser@gmu.edu
Summary
Peripheral fatigue, a decline in muscle function, stems from non-central mechanisms. It is exacerbated by product inhibition within muscle cells, impacting endurance and quality of life.
Area of Science:
- Exercise Physiology
- Skeletal Muscle Biology
- Biochemistry
Background:
- Peripheral fatigue is a decline in muscle function not originating from the central nervous system.
- It is characterized by tiredness due to overexertion, worsened by poor physical fitness and chronic illnesses.
- Fatigue can significantly limit physical and social functioning, diminishing quality of life.
Purpose of the Study:
- To provide an overview of the common pathways mediating peripheral fatigue.
- To highlight product inhibition of contractile chemistry as a key mechanism.
- To explain how metabolite accumulation affects muscle function.
Main Methods:
- Review of existing literature on peripheral fatigue mechanisms.
- Analysis of the role of adenosine triphosphate hydrolysis products.
- Focus on the final mediation occurring within muscle cells.
Main Results:
- Peripheral fatigue involves overactivity-induced decline in muscle function.
- Accumulation of products from adenosine triphosphate hydrolysis inhibits crossbridge functioning.
- This leads to limitations in muscle or cardiorespiratory endurance (fatigue resistance).
Conclusions:
- Product inhibition of contractile chemistry is a central pathway in peripheral fatigue.
- Understanding these mechanisms is crucial for addressing fatigue-related limitations.
- Peripheral fatigue ultimately results from altered muscle cell function.
More Related Videos
07:18High-Resolution Fluorespirometry to Assess Dynamic Changes in Mitochondrial Membrane Potential in Human Immune Cells
Published on: May 24, 2024
09:53High-Resolution Respirometry to Assess Bioenergetics in Cells and Tissues Using Chamber- and Plate-Based Respirometers
Published on: October 26, 2021
Related Concept Videos
01:24Muscle Recovery and Fatigue
Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective response...
01:31ATP Energy Storage and Release
ATP is a highly unstable molecule. Unless quickly used to perform work, ATP spontaneously dissociates into ADP and inorganic phosphate (Pi), and the free energy released during this process is lost as heat. The energy released by ATP hydrolysis is used to perform work inside the cell and depends on a strategy called energy coupling. Cells couple the exergonic reaction of ATP hydrolysis with endergonic reactions, allowing them to proceed.
One example of energy coupling using ATP involves a...
One example of energy coupling using ATP involves a...
01:31ATP Energy Storage and Release
ATP is a highly unstable molecule. Unless quickly used to perform work, ATP spontaneously dissociates into ADP and inorganic phosphate (Pi), and the free energy released during this process is lost as heat. The energy released by ATP hydrolysis is used to perform work inside the cell and depends on a strategy called energy coupling. Cells couple the exergonic reaction of ATP hydrolysis with endergonic reactions, allowing them to proceed.
One example of energy coupling using ATP involves a...
One example of energy coupling using ATP involves a...
01:23ATP and Energy Production
Adenosine triphosphate (ATP) is a critical molecule that functions as the main energy carrier in cells. Structurally, ATP consists of an adenosine molecule—comprising adenine and ribose—bonded to three phosphate groups. The high-energy bonds between these phosphate groups store significant amounts of potential energy. This energy is released during hydrolysis, wherein ATP is converted to adenosine diphosphate (ADP) or adenosine monophosphate (AMP), driving a variety of essential cellular...
01:27ATP Driven Pumps I: An Overview
ATP-driven pumps, also known as transport ATPases, are integral membrane proteins. They have binding sites for ATP located on the membrane's cytosolic side and the ion-conducting domain in the transmembrane region. These pumps use the free energy released from ATP hydrolysis to move the solutes across cell membranes against an electrochemical gradient.
There are four main types of ATP-driven pumps - P-type, V-type, F-type, and ABC transporter. All these pumps are of varying complexities and are...
There are four main types of ATP-driven pumps - P-type, V-type, F-type, and ABC transporter. All these pumps are of varying complexities and are...
01:08Hydrolysis of ATP
The bonds of adenosine triphosphate (ATP) can be broken through the addition of water, releasing one or two phosphate groups in an exergonic process called hydrolysis. This reaction liberates the energy in the bonds for use in the cell—for instance, to synthesize proteins from amino acids.
If one phosphate group is removed, a molecule of ADP—adenosine diphosphate—remains, along with inorganic phosphate. ADP can be further hydrolyzed to AMP—adenosine monophosphate—by the removal of a second...
If one phosphate group is removed, a molecule of ADP—adenosine diphosphate—remains, along with inorganic phosphate. ADP can be further hydrolyzed to AMP—adenosine monophosphate—by the removal of a second...