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Eosinophilic chronic rhinosinusitis in Japan
Junichi Ishitoya1, Yasunori Sakuma2, Mamoru Tsukuda3
1Department of Otorhinolaryngology, Yokohama City University Medical Center Graduate School of Medicine, Kanagawa, Japan..
Summary
Eosinophilic chronic rhinosinusitis (ECRS) is a distinct subtype of chronic rhinosinusitis with nasal polyps (CRSwNP) prevalent in East Asia. This review details ECRS clinical features, diagnosis, and treatment, proposing its applicability globally.
Area of Science:
- Otolaryngology
- Immunology
Background:
- Chronic rhinosinusitis (CRS) is classified into CRSwNP and CRSsNP in Western countries.
- CRSwNP typically involves eosinophilic inflammation and recurrence post-surgery.
- This classification is challenging in East Asia where many CRSwNP cases lack eosinophilic dominance.
Purpose of the Study:
- To review the distinct clinical features of ECRS, a specific subtype of CRSwNP identified in Japan.
- To outline diagnostic criteria and treatment strategies for ECRS.
- To discuss the pathophysiology and global applicability of the ECRS concept.
Main Methods:
- Review of clinical studies and literature focusing on refractory CRSwNP in Japan.
- Comparative analysis of clinical features differentiating ECRS from non-ECRS.
- Discussion of diagnostic and therapeutic approaches.
Main Results:
- ECRS presents unique clinical characteristics including symptom presentation, polyp location, CT findings, histology, blood markers, surgical outcomes, and comorbidities like asthma.
- ECRS is distinguished from non-ECRS by these varied clinical features.
- The concept of ECRS offers a framework for understanding CRSwNP globally.
Conclusions:
- ECRS represents a clinically significant subgroup of CRSwNP with specific features.
- Accurate diagnosis and tailored treatment are crucial for managing ECRS.
- The ECRS classification may enhance the understanding and management of CRSwNP worldwide.
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