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Solid Phase Synthesis of a Functionalized Bis-Peptide Using "Safety Catch" Methodology
Published on: May 15, 2012
Solid-phase synthesis of new Trp(Nps)-containing dipeptide derivatives as TRPV1 channel blockers
Ma Jesús Pérez de Vega1, Ma Teresa García-López, Laura Zaccaro
1Instituto de Química Médica, CSIC, Juan de la Cierva, 3, 28006 Madrid, Spain.
Molecules (Basel, Switzerland)
|July 27, 2010
Abstract:
Trp(Nps)-Lys-NH(2) derivatives, bearing alkyl or guanidine groups either at the N-terminus or on the Lys side-chain or at both positions were conveniently prepared on solid-phase and evaluated as TRPV1 channel antagonists.
