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Updated: Jun 10, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

Arterial aging--hemodynamic changes and therapeutic options.

Michel E Safar¹

¹Diagnosis Center, Hôpital Hôtel-Dieu, 1 Place du Parvis Notre-Dame, 75181 Paris Cedex 04, France michel.safar@htd.aphp.fr.

Nature Reviews. Cardiology

|July 27, 2010

Summary

This summary is machine-generated.

Arterial aging increases stiffness and wave reflections, raising blood pressure and cardiovascular risk. Pharmacological therapies targeting these changes improve outcomes, predictable by measuring central blood pressure.

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Last Updated: Jun 10, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

Area of Science:

Cardiovascular Physiology
Gerontology
Pharmacology

Background:

Arterial aging involves increased arterial stiffness and disturbed wave reflections.
Reduced aortic capacity diminishes pulsatile flow dampening, increasing systolic and pulse pressures.
These hemodynamic changes elevate cardiovascular event risk.

Purpose of the Study:

To explore the pathophysiological mechanisms of arterial aging.
To investigate pharmacological therapies for arterial stiffness and wave reflections.
To correlate therapeutic outcomes with noninvasive hemodynamic measurements.

Main Methods:

Review of pathophysiological changes in arterial aging.
Analysis of pharmacological interventions targeting renin-angiotensin-aldosterone pathway.
Correlation of cardiovascular outcomes with central systolic blood pressure and pulse pressure measurements.

Main Results:

Arterial stiffness and wave reflections are key to age-related blood pressure increase.
Pharmacological therapies, particularly antifibrotic agents, improve cardiovascular outcomes.
These improvements are linked to reduced arterial stiffness and wave reflections.
Noninvasive measurements predict treatment efficacy.

Conclusions:

Pharmacological therapies targeting arterial stiffness and wave reflections are effective in managing cardiovascular risk in aging populations.
Understanding pulsatile hemodynamics is crucial for predicting treatment success.
Central blood pressure monitoring aids in assessing therapeutic benefits.