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Procedure for Fabricating Biofunctional Nanofibers
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Cyclodextrin nanofibers by electrospinning.

Asli Celebioglu1, Tamer Uyar

  • 1UNAM-Institute of Materials Science & Nanotechnology, Bilkent University, Ankara, 06800, Turkey.

Chemical Communications (Cambridge, England)
|July 27, 2010
PubMed
Summary

Cyclodextrin nanofibers were successfully electrospun using methyl-beta-cyclodextrin. Key factors for successful electrospinning include solvent choice, concentration, and molecular interactions.

Area of Science:

  • Materials Science
  • Polymer Science

Background:

  • Cyclodextrins (CDs) are cyclic oligosaccharides with unique host-guest properties.
  • Electrospinning is a versatile technique for fabricating polymer nanofibers.

Purpose of the Study:

  • To investigate the direct electrospinning of cyclodextrin (CD) into nanofibers.
  • To identify critical parameters influencing the electrospinning of CD nanofibers.

Main Methods:

  • Direct electrospinning of methyl-beta-cyclodextrin (MbetaCD) solutions.
  • Systematic variation of solvent type and CD concentration.
  • Analysis of intermolecular interactions during electrospinning.

Main Results:

  • Successful fabrication of MbetaCD nanofibers without blending with other polymers.

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  • Demonstrated dependence of electrospinning success on solvent properties.
  • Highlighted the crucial role of solution concentration and intermolecular forces.

    • Conclusions:

    • Cyclodextrins can be electrospun into nanofibers independently.
    • Optimizing solvent, concentration, and understanding molecular interactions are vital for CD nanofiber production.