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Related Concept Videos

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Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
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Recent Advances in Cyclodextrin-Based Nanoscale Drug Delivery Systems.

Fuat Topuz1, Tamer Uyar2

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PubMed
Summary
This summary is machine-generated.

Cyclodextrins (CDs) are versatile cyclic oligosaccharides used in drug delivery. Their unique structure enhances drug solubility, bioavailability, and stability in various nanoscale systems.

Keywords:
MOFscyclodextrindrug deliveryelectrospinninggrapheneliposomesnanofibersnanoparticlesquantum dots

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Area of Science:

  • Biochemistry and Pharmaceutical Sciences
  • Materials Science and Nanotechnology

Background:

  • Cyclodextrins (CDs) are cyclic oligosaccharides with a toroidal shape, featuring a hydrophobic interior and hydrophilic exterior.
  • This structure enables CDs to act as solubilizers, stabilizers, and bioavailability enhancers in pharmaceutical formulations.
  • CDs are increasingly integrated into nanoscale drug delivery systems due to their versatile properties.

Purpose of the Study:

  • To review recent advancements in cyclodextrin-functionalized nanoscale drug delivery platforms.
  • To analyze the physicochemical and toxicological aspects of CDs and their impact on drug bioavailability.
  • To summarize the applications of CD-based nanomaterials in drug delivery.

Main Methods:

  • Compilation and analysis of recent scientific literature on CD-functional nanoscale drug delivery systems.
  • Review of studies focusing on physicochemical properties, toxicological profiles, and drug complexation of CDs.
  • Categorization of applications based on nanomaterial type (polymeric, hybrid, lipid-based, nanofibers) and CD function.

Main Results:

  • CDs effectively solubilize hydrophobic drugs, enabling high drug loading and enhancing bioavailability.
  • Supramolecular complexation with CDs facilitates the engineering of advanced nanomaterials.
  • CD-functionalized systems, including nanoparticles and nanofibers, demonstrate significant potential for drug delivery applications.
  • CDs are primarily used for drug solubilization and loading, with some applications utilizing supramolecular complexation for system construction.

Conclusions:

  • Cyclodextrin-based nanoscale drug delivery systems offer significant advantages in drug solubilization, loading, bioavailability enhancement, and stability.
  • The versatility of CDs allows for their integration into diverse nanomaterial platforms for targeted therapeutic applications.
  • Further research is needed to address current challenges and optimize the future development of CD-functionalized drug delivery systems.