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Yeast As a Chassis for Developing Functional Assays to Study Human P53
Published on: August 4, 2019
p53 codon 72 polymorphism association with head and neck squamous cell carcinoma
Zahra Mojtahedi1, Seyed Basir Hashemi, Bijan Khademi
1Shiraz Insttute for Cancer Research, Shiraz University of Medical Sciences, Shiraz, Iran.
Brazilian Journal of Otorhinolaryngology
|July 27, 2010
Summary
The p53 codon 72 polymorphism does not influence head and neck squamous cell carcinoma (HNSCC) risk in Iranians. However, the Pro/Pro genotype is linked to advanced tumor stage (IV) and increased risk in HNSCC patients.
Area of Science:
- Genetics
- Oncology
- Molecular Biology
Background:
- The p53 tumor suppressor gene has a functional polymorphism at codon 72, resulting in either arginine (Arg) or proline (Pro) variants.
- This p53 codon 72 polymorphism has been implicated in the development and prognosis of head and neck squamous cell carcinoma (HNSCC).
Purpose of the Study:
- To investigate the allelic frequencies and genotype distribution of the p53 codon 72 polymorphism in Iranian patients with HNSCC.
- To determine the association between p53 codon 72 polymorphism and HNSCC risk, as well as clinicopathological features in the Iranian population.
Main Methods:
- A case-control study involving 132 HNSCC patients and 123 healthy controls from Iran.
- Genotyping was performed using allele-specific polymerase chain reaction (PCR) on DNA extracted from peripheral blood mononuclear cells.
Main Results:
- No significant differences in p53 codon 72 allele frequencies or genotype distribution were observed between HNSCC patients and healthy controls.
- The Pro/Pro genotype showed a significant increase in Stage IV HNSCC patients (30.8%) compared to Stages I-III (11.1%) (p=0.03).
- A higher percentage of patients with the Pro allele were associated with an increased risk of developing Stage IV disease (OR=2.2, 95% CI=1.2-4.2, p=0.01).
Conclusions:
- The p53 codon 72 polymorphism does not appear to influence the overall risk of developing HNSCC in the Iranian population.
- This polymorphism may play a role in the progression of HNSCC, specifically correlating with advancement to higher tumor stages.
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