[Functional concept of the initiation of blood coagulation by cell membranes]

According to the conception proposed, blood coagulation is initiated by Ca(2+)-induced rearrangement of the bilayer structure of native cell membranes into heterophasic. The thrombogenic action is realized through Ca2+ entering the cell cytoplasm. This leads to phosphatidyl serine translocation into the surface monolayer of the membrane, its clustering and the arising of phosphatidyl ethanolamine mesophases. Vitamin K-dependent coagulation factors are bound at the boundaries of clusters and mesophases of these phospholipids through Ca2+ ions. They form enzyme complexes functioning due to the matrix structure of phospholipid surface as units of thrombin generation.