Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Nucleus01:25

The Nucleus

The nucleus is a membrane-bound organelle that acts as a control center in a eukaryotic cell. It contains chromosomal DNA, which controls gene expression and precisely regulates the production of proteins within the cell. In contrast, the DNA inside the mitochondria and chloroplast only carries out functions that are specific to those organelles.
Arrangement of DNA within Nucleus
The regulation of gene expression inside the nucleus is dependent on many factors, including the DNA structure. The...
The Nucleus01:32

The Nucleus

The nucleus is a membrane-bound organelle that acts as a control center in a eukaryotic cell. It contains chromosomal DNA, which controls gene expression and precisely regulates the production of proteins within the cell. In contrast, the DNA inside the mitochondria and chloroplast only carries out functions that are specific to those organelles.
Arrangement of DNA within Nucleus
The regulation of gene expression inside the nucleus is dependent on many factors, including the DNA structure. The...
The Nucleus01:25

The Nucleus

The nucleus is a membrane-bound organelle that acts as a control center in a eukaryotic cell. It contains chromosomal DNA, which controls gene expression and precisely regulates the production of proteins within the cell. In contrast, the DNA inside the mitochondria and chloroplast only carries out functions that are specific to those organelles.
Arrangement of DNA within Nucleus
The regulation of gene expression inside the nucleus is dependent on many factors, including the DNA structure. The...
Atomic Nuclei: Nuclear Spin State Overview01:03

Atomic Nuclei: Nuclear Spin State Overview

NMR-active nuclei have energy levels called 'spin states' that are associated with the orientations of their nuclear magnetic moments. In the absence of a magnetic field, the nuclear magnetic moments are randomly oriented, and the spin states are degenerate. When an external magnetic field is applied, the spin states have only 2 + 1 orientations available to them. A proton with = ½ has two available orientations. Similarly, for a quadrupolar nucleus with a nuclear spin value of one, the...
Atomic Nuclei: Nuclear Spin01:08

Atomic Nuclei: Nuclear Spin

All atomic particles possess an intrinsic angular momentum, or 'spin'. Electrons, protons, and neutrons each have a spin value of ½, although protons and neutrons in nuclei may have higher half-integer spins owing to energetic factors.
Atomic nuclei have a net nuclear spin, , which can have an integer or half-integer value. In atomic nuclei, the spins of protons are paired against each other but not with neutrons, and vice versa. Consequently, an even number of protons does not contribute to...
Atomic Nuclei: Nuclear Spin State Population Distribution01:14

Atomic Nuclei: Nuclear Spin State Population Distribution

Near absolute zero temperatures, in the presence of a magnetic field, the majority of nuclei prefer the lower energy spin-up state to the higher energy spin-down state. As temperatures increase, the energy from thermal collisions distributes the spins more equally between the two states. The Boltzmann distribution equation gives the ratio of the number of spins predicted in the spin −½ (N−) and spin +½ (N+) states.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Untold: Marshall Nirenberg and Hexose Transport.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
Same author

A totipotent embryologist: John B. Gurdon (1933-2025).

Genes & development·2025
Same author

Cellular infrastructure: X-rays have just made another soft landing.

Molecular biology of the cell·2025
Same author

David Baltimore and the advent of eukaryotic RNA-binding proteins.

Molecular biology of the cell·2025
Same author

Étienne-Émile Baulieu (1926-2025): Scientist of steroids and champion of women's reproductive rights.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Étienne-Émile Baulieu (1929-2025): Scientist of steroids and champion of women's reproductive rights.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same journal

Evolutionary and Biochemical Perspectives on the Incorporation and Utilization of Selenocysteine.

Cold Spring Harbor perspectives in biology·2026
Same journal

The Mitochondrial Calcium Uniporter: From Parts to Signaling Networks.

Cold Spring Harbor perspectives in biology·2026
Same journal

Growth Control and Beyond: Functional Diversity and Regulation of the Hippo Pathway in the Nervous System.

Cold Spring Harbor perspectives in biology·2026
Same journal

Structural Studies of Core Hippo Pathway Components.

Cold Spring Harbor perspectives in biology·2026
Same journal

The Hippo Pathway in Intestinal Regeneration, Fetal Reprogramming, and Tumorigenesis.

Cold Spring Harbor perspectives in biology·2026
Same journal

A Synergy between Genetics and Biochemistry Unravels the Molecular Architecture of the Hippo Signaling Pathway.

Cold Spring Harbor perspectives in biology·2026
See all related articles

Related Experiment Video

Updated: Jun 10, 2026

A Direct Force Probe for Measuring Mechanical Integration Between the Nucleus and the Cytoskeleton
05:47

A Direct Force Probe for Measuring Mechanical Integration Between the Nucleus and the Cytoskeleton

Published on: July 29, 2018

The nucleus introduced.

Thoru Pederson1

  • 1Program in Cell and Developmental Dynamics, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA. thoru.pederson@umassmed.edu

Cold Spring Harbor Perspectives in Biology
|July 28, 2010
PubMed
Summary
This summary is machine-generated.

The cell nucleus is dynamic and its organization, including gene location, is key to its functions. This timely review explores the evolving understanding of nuclear structure and function.

More Related Videos

Combining 3D Magnetic Force Actuator and Multi-Functional Fluorescence Imaging to Study Nucleus Mechanobiology
06:54

Combining 3D Magnetic Force Actuator and Multi-Functional Fluorescence Imaging to Study Nucleus Mechanobiology

Published on: July 5, 2022

Intranuclear Microinjection of DNA into Dissociated Adult Mammalian Neurons
13:39

Intranuclear Microinjection of DNA into Dissociated Adult Mammalian Neurons

Published on: December 10, 2009

Related Experiment Videos

Last Updated: Jun 10, 2026

A Direct Force Probe for Measuring Mechanical Integration Between the Nucleus and the Cytoskeleton
05:47

A Direct Force Probe for Measuring Mechanical Integration Between the Nucleus and the Cytoskeleton

Published on: July 29, 2018

Combining 3D Magnetic Force Actuator and Multi-Functional Fluorescence Imaging to Study Nucleus Mechanobiology
06:54

Combining 3D Magnetic Force Actuator and Multi-Functional Fluorescence Imaging to Study Nucleus Mechanobiology

Published on: July 5, 2022

Intranuclear Microinjection of DNA into Dissociated Adult Mammalian Neurons
13:39

Intranuclear Microinjection of DNA into Dissociated Adult Mammalian Neurons

Published on: December 10, 2009

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Genetics

Background:

  • The nucleus, a central organelle in eukaryotic cells, has long been studied for its role in housing genetic material.
  • Recent decades have seen a paradigm shift, establishing the nucleus as a highly dynamic structure.
  • Emerging evidence highlights the importance of nuclear organization in regulating cellular processes.

Purpose of the Study:

  • To review the dynamic nature of the cell nucleus.
  • To explore the relationship between nuclear organization and function.
  • To discuss emerging concepts in nuclear architecture and its implications.

Main Methods:

  • Literature review of recent advancements in nuclear biology.
  • Synthesis of findings on nuclear dynamics and organization.
  • Conceptual framework development for understanding nuclear function.

Main Results:

  • The nucleus is not static but a highly dynamic entity.
  • Nuclear organization, including gene positioning, significantly influences gene expression and other nuclear functions.
  • Self-organizing bodies within the nucleus are increasingly recognized as functional units.

Conclusions:

  • Understanding nuclear dynamics and organization is crucial for comprehending cell biology.
  • Future research will likely focus on the interplay between nuclear structure and function.
  • The dynamic and organized nucleus represents a key frontier in biological research.