[Synthetic progestogens versus oral progesterone]

The antecedents of progesterone natural hormone and related structural groups, chemically and biologically, were described. The synthesis and semi-synthesis of these compounds, is reviewed, and molecular changes, which gave more potency for clinical use, is reviewed. The pharmacology of these groups is manifested, particularly, by the identification of a receptor, its physico-quemical characteristics and relative affinity for tissues as endometrium and myometrium. Furthermore, the progestational quality, the antiestrogenic one, antiandrogenic one and its applications, were evaluated. Finally, several biologic indicators which support the use of oral progesterone and that suggest the re-evaluation of tissular dynamics in reproductive tract, were reviewed.