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Doxycycline failure in lymphogranuloma venereum
Frédéric Méchaï1, Bertille de Barbeyrac, Olivier Aoun
1Service des Maladies Infectieuses et Tropicales, Hôpital d'Instruction des Armées Bégin, Saint Mandé 94160, France. mechaifrederic@wanadoo.fr
Sexually Transmitted Infections
|July 28, 2010
Summary
Lymphogranuloma venereum (LGV) is re-emerging, especially in HIV-positive men. Moxifloxacin offers a potential alternative treatment for LGV when doxycycline therapy fails.
Area of Science:
- Infectious Diseases
- Microbiology
- Public Health
Background:
- Lymphogranuloma venereum (LGV) is a sexually transmitted infection caused by specific serotypes of Chlamydia trachomatis.
- LGV is re-emerging globally, particularly within men who have sex with men (MSM) communities, with a notable increase in HIV-seropositive individuals.
- The standard treatment for LGV involves a 3-week course of doxycycline.
Observation:
- A case of LGV in a male patient is presented.
- The patient did not respond to extended treatment with doxycycline.
- The patient was subsequently treated with moxifloxacin.
Findings:
- Moxifloxacin treatment resulted in a rapid cure of the LGV infection.
- In vitro studies demonstrate high activity of fluoroquinolones, including moxifloxacin, against the LGV agent.
- This suggests moxifloxacin's efficacy in treating LGV.
Implications:
- Moxifloxacin may serve as a valuable alternative treatment option for LGV.
- This is particularly relevant for cases where standard doxycycline therapy is ineffective or fails.
- Further research into fluoroquinolone efficacy for LGV is warranted to guide clinical practice.
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