Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Differential Effects of Low-Intensity Pulsed Ultrasound and Antifungals on <i>Candida albicans</i> and <i>Candida glabrata</i>: Implications for Drug Efficacy.

Journal of fungi (Basel, Switzerland)·2026
Same author

Differential Myelin and Axon-Dependent Recovery Based on Symptom Duration in Degenerative Cervical Myelopathy.

Neurosurgery·2026
Same author

Machine learning-based MRI radiomics identifies patients with degenerative cervical myelopathy and predicts baseline function.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·2026
Same author

Spinal Cord Radiomics-Driven Machine Learning Predicts Meaningful Clinical Improvement After Surgery for Degenerative Cervical Myelopathy: A Pilot Study.

Journal of imaging informatics in medicine·2026
Same author

A closed-head, rotational traumatic brain injury model demonstrates deficits in righting reflex, neurological function, and auditory brainstem responses in rats.

Brain injury·2026
Same author

Body size and intracranial volume interact with the structure of the central nervous system: A multi-center in vivo neuroimaging study.

Imaging neuroscience (Cambridge, Mass.)·2025
Same journal

Chemotactic self-organization captures the dynamics of mammalian hair follicle patterning.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Tomographic imaging of superconducting order using particle-hole interference.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Inhibitory potential of autologous neutralizing antibodies sets quantitative limits on the rebound-competent HIV-1 reservoir.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Inferring epidemiological parameters under an infectious phylogeography model with visitor dynamics.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Analytical modeling for suction cup designs for skin-interfaced wearable devices.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Improving cell-free metabolism through direct integration of artificial respiratory chains.

Proceedings of the National Academy of Sciences of the United States of America·2026
See all related articles

Related Experiment Video

Updated: Jun 10, 2026

Quantification of Neurovascular Protection Following Repetitive Hypoxic Preconditioning and Transient Middle Cerebral Artery Occlusion in Mice
09:48

Quantification of Neurovascular Protection Following Repetitive Hypoxic Preconditioning and Transient Middle Cerebral Artery Occlusion in Mice

Published on: May 4, 2015

Neurite beading is sufficient to decrease the apparent diffusion coefficient after ischemic stroke.

Matthew D Budde1, Joseph A Frank

  • 1Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA. buddem@mail.nih.gov

Proceedings of the National Academy of Sciences of the United States of America
|July 28, 2010
PubMed
Summary
This summary is machine-generated.

Neurite beading, not just cell swelling, significantly decreases water diffusion in the brain after stroke. This finding improves the specificity of Diffusion-Weighted MRI (DWI) for detecting acute neurological injuries.

More Related Videos

Middle Cerebral Artery Occlusion Allowing Reperfusion via Common Carotid Artery Repair in Mice
06:59

Middle Cerebral Artery Occlusion Allowing Reperfusion via Common Carotid Artery Repair in Mice

Published on: January 23, 2019

A Versatile Murine Model of Subcortical White Matter Stroke for the Study of Axonal Degeneration and White Matter Neurobiology
08:36

A Versatile Murine Model of Subcortical White Matter Stroke for the Study of Axonal Degeneration and White Matter Neurobiology

Published on: March 17, 2016

Related Experiment Videos

Last Updated: Jun 10, 2026

Quantification of Neurovascular Protection Following Repetitive Hypoxic Preconditioning and Transient Middle Cerebral Artery Occlusion in Mice
09:48

Quantification of Neurovascular Protection Following Repetitive Hypoxic Preconditioning and Transient Middle Cerebral Artery Occlusion in Mice

Published on: May 4, 2015

Middle Cerebral Artery Occlusion Allowing Reperfusion via Common Carotid Artery Repair in Mice
06:59

Middle Cerebral Artery Occlusion Allowing Reperfusion via Common Carotid Artery Repair in Mice

Published on: January 23, 2019

A Versatile Murine Model of Subcortical White Matter Stroke for the Study of Axonal Degeneration and White Matter Neurobiology
08:36

A Versatile Murine Model of Subcortical White Matter Stroke for the Study of Axonal Degeneration and White Matter Neurobiology

Published on: March 17, 2016

Area of Science:

  • Neuroscience
  • Biophysics
  • Medical Imaging

Background:

  • Diffusion-weighted MRI (DWI) is crucial for detecting cerebral ischemia.
  • Apparent diffusion coefficient (ADC) decreases in ischemic regions, but the exact cause is unclear.
  • Cell swelling is a suspected but not fully understood contributor to ADC changes.

Purpose of the Study:

  • To investigate the role of neurite beading in ADC changes during ischemia.
  • To develop and validate a biophysical model of neurite beading and its effect on water diffusion.
  • To enhance the specificity of DWI in diagnosing acute neurological injuries.

Main Methods:

  • Derived a biophysical model of neurite beading based on osmotic imbalance.
  • Simulated DWI experiments using the biophysical model to calculate ADC changes in beaded neurites.
  • Experimentally validated the model using excised rat sciatic nerves subjected to stretching to induce beading.

Main Results:

  • Neurite beading, characterized by focal enlargement and constriction, was shown to significantly decrease ADC.
  • The biophysical model predicted a 79% decrease in intracellular ADC for beaded neurites.
  • Experimental results with rat sciatic nerves confirmed that beading-induced morphological changes, independent of swelling, hinder water mobility and lower ADC.

Conclusions:

  • Neurite beading is a primary mechanism driving the decrease in ADC observed in DWI of ischemic brain.
  • The findings demonstrate that neurite beading accurately reflects diffusion changes measured in vivo.
  • This research advances DWI specificity for ischemia and neurological injuries, aiding treatment development.