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The prognostic value of mean platelet volume in decompensated heart failure
Hayati Kandis1, Hakan Ozhan, Serkan Ordu
1Duzce University, Düzce Medical School, Department of Emergency Medicine, Konuralp Düzce, Turkey.
Insights
Mean platelet volume (MPV) is higher in patients with decompensated heart failure (DHF) and predicts mortality. Elevated MPV levels on admission indicate increased risk for in-hospital and 6-month mortality in DHF patients.
Area of Science:
- Cardiology
- Hematology
- Public Health
Background:
- Congestive heart failure (CHF) significantly impacts public health, causing morbidity, reduced quality of life, and mortality.
- Mean platelet volume (MPV) serves as a marker for platelet activation.
Purpose of the Study:
- To compare MPV levels between decompensated heart failure (DHF) and stable heart failure (SHF) patients.
- To evaluate the prognostic significance of MPV in DHF for predicting mortality.
Main Methods:
- 136 DHF patients and 71 SHF patients were enrolled.
- Patients were followed for a mean of 18 months, with death from any cause as the primary endpoint.
- Clinical characteristics and MPV levels were compared between survivors and non-survivors.
Main Results:
- MPV was significantly elevated in the DHF group compared to the SHF group.
- MPV was identified as an independent risk factor for mortality in DHF patients (OR 1.553).
- MPV on admission demonstrated predictive value for in-hospital (AUC 0.716) and 6-month mortality (AUC 0.815).
Conclusions:
- Mean platelet volume is increased in patients experiencing decompensated heart failure.
- MPV levels at admission are a significant independent predictor of both in-hospital and 6-month mortality in DHF patients.
Background:
Congestive heart failure (CHF) is a major public health problem that is related to substantial morbidity, impaired quality of life and diminished survival. Mean platelet volume (MPV) is an indicator of platelet activation.
Aim:
To investigate whether there is a difference of MPV in patients with decompensated and stable heart failure (SHF), and test the prognostic value of MPV in decompensated heart failure (DHF).
Methods:
136 consecutive patients with DHF were enrolled. 71 with SHF were also enrolled for comparison. Patients were followed up for a mean of 18±12 months. The primary endpoint was death from any cause. Clinical characteristics of patients with DHF who died during follow-up were compared with the those of the survivors.
Results:
MPV was significantly higher in DHF group than in the SHF group. 71 patients died during the follow-up period (18±12 months). Comparison with survivors revealed that mortality was associated with age, systolic blood pressure, pulmonary artery pressure, serum creatinine, urea and MPV. MPV was determined as an independent risk factor for mortality (OR 1.553, 95% CI 1.024 to 2.354, p=0.038). Receiver operating characteristic analysis showed that MPV level on admission was a predictor of mortality (area under the curve (AUC) for in-hospital mortality was 0.716 (95% CI 0.632 to 0.789, p=0.003) and AUC for 6-month mortality was 0.815 (95% CI 0.74 to 0.877, p<0.001), respectively).
Conclusion:
MPV is increased in patients with DHF. Also, MPV on admission is an independent predictor of in-hospital mortality and 6-month mortality.
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