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Association Between History of Polymerase Chain Reaction-verified COVID-19 Infection and Outcomes of Subsequent

Zeki Dogan1, Ismail Erden1, Gokhan Bektasoglu1

  • 1Department of Cardiology, Atlas University Medical Faculty Medicine Hospital, Istanbul, Turkey.

Angiology
|November 18, 2022
PubMed

Insights

A history of COVID-19 infection increases the risk of major adverse cardiac events (MACE) in ST-segment elevation myocardial infarction (STEMI) patients post-intervention. This finding highlights the long-term cardiac impact of COVID-19 on STEMI outcomes.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Public Health

Background:

  • The acute phase of COVID-19 is linked to adverse cardiac outcomes.
  • The long-term impact of prior COVID-19 infection on ST-segment elevation myocardial infarction (STEMI) outcomes remains unclear.
  • Previous studies compared STEMI during the pandemic to pre-pandemic periods, not focusing on COVID-19 history within the pandemic.

Purpose of the Study:

  • To investigate the association between a history of COVID-19 infection and outcomes in patients with STEMI during the pandemic.
  • To compare clinical and angiographic characteristics and in-hospital major adverse cardiac events (MACE) between STEMI patients with and without a history of COVID-19.
  • To determine if a history of COVID-19 independently predicts MACE in STEMI patients.

Main Methods:

  • Retrospective analysis of Ministry of Health database for patients diagnosed with STEMI during the COVID-19 pandemic.
  • Categorization of patients into two groups: those with (n=191) and without (n=127) a history of PCR-confirmed COVID-19 infection.
  • Assessment of clinical, angiographic characteristics, procedural findings, and in-hospital MACE.

Main Results:

  • STEMI patients with a history of PCR-verified COVID-19 infection exhibited higher rates of in-hospital MACE.
  • Patients without a history of COVID-19 showed better angiographic and procedural findings indicative of successful reperfusion.
  • A history of COVID-19 infection was identified as an independent predictor of MACE (odds ratio 1.40, 95% CI 1.25-1.60, P < .01).

Conclusions:

  • A history of COVID-19 infection is associated with worse outcomes following coronary intervention in STEMI patients.
  • Prior COVID-19 infection independently predicts an increased risk of in-hospital MACE among STEMI patients.
  • These findings underscore the significant long-term cardiovascular implications of COVID-19 in patients experiencing myocardial infarction.

Keywords:
COVID-19ST-elevation myocardial infarctionprimary percutaneous coronary intervention

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