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Related Experiment Video

Updated: Jun 10, 2026

In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein

In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein

Published on: January 2, 2015

Intracellular and extracellular tau.

¹Centro de Biología Molecular "Severo Ochoa", Campus Cantoblanco, Universidad Autónoma de Madrid Madrid, Spain.

Frontiers in Neuroscience

|July 28, 2010

Summary

This review covers the toxicity of modified intracellular tau protein and extracellular tau released after neuron death. Understanding tau toxicity is crucial for neurodegenerative disease research.

Area of Science:

Neuroscience
Cell Biology
Toxicology

Background:

Tau protein plays a critical role in neuronal function.
Aberrant tau pathology is a hallmark of several neurodegenerative diseases.
Both intracellular and extracellular tau species can exert toxic effects.

Purpose of the Study:

To review the toxicity associated with modified intracellular tau.
To discuss the toxicity of extracellular tau released post-neuron death.
To consolidate understanding of tau's dual localization toxicity.

Main Methods:

Literature review of existing studies on tau protein.
Analysis of research on intracellular tau modifications.
Examination of studies investigating extracellular tau release and toxicity.

Keywords:

Alzheimer disease tau tauopathies toxicity

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Main Results:

Modified intracellular tau exhibits significant toxicity.
Extracellular tau, released from dying neurons, also contributes to neurotoxicity.
Tau's toxicity is dependent on its localization and modification state.

Conclusions:

Both intracellular and extracellular tau species are toxic.
Tau pathology contributes to neurodegeneration through multiple mechanisms.
Further research into tau toxicity is warranted for therapeutic development.