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[Resected pleomorphic carcinoma after long-time follow-up]
Tsuyoshi Takahashi1, Atsushi Sano, Yukihiro Yoshida
1Department of Cardiothoracic Surgery, The University of Tokyo, Graduate School of Medicine, Tokyo, Japan.
This case study details the surgical resection of a rare pulmonary pleomorphic carcinoma in a 75-year-old male. The tumor showed gradual growth over six years, presenting as a nodule within a cavity.
Area of Science:
- Pulmonology
- Thoracic Surgery
- Oncology
Background:
- Pulmonary pleomorphic carcinoma is a rare and aggressive lung malignancy.
- Early detection and surgical intervention are crucial for improved patient outcomes.
Observation:
- A 75-year-old male presented with a gradually enlarging lung nodule over six years.
- Chest CT revealed a nodule within a cavity, exhibiting progressive growth.
- The patient had multiple comorbidities, precluding adjuvant therapy.
Findings:
- Histopathology confirmed a pleomorphic carcinoma with components of adenocarcinoma and spindle cell features.
- Immunohistochemistry supported the diagnosis, with differential expression of TTF-1.
- Surgical wedge resection was performed due to the patient's poor physical condition.
Implications:
- This case highlights the importance of long-term imaging surveillance for lung nodules.
- Surgical resection can be a viable option for pulmonary pleomorphic carcinoma, even in elderly patients with comorbidities.
- Understanding the heterogeneous nature of pleomorphic carcinoma is key for accurate diagnosis and treatment planning.
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