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Epigenetic Regulation

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.

Epigenetic Regulation

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...

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Related Experiment Video

Updated: Jun 10, 2026

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer

Published on: September 18, 2020

DNA methylation profiling in cancer.

Yutaka Kondo¹, Jean-Pierre J Issa

¹Division of Molecular Oncology, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan. ykondo@aichi-cc.jp

Expert Reviews in Molecular Medicine

|July 29, 2010

Summary

This summary is machine-generated.

Aberrant DNA methylation patterns are hallmarks of cancer, often silencing tumor-suppressor genes. Understanding these epigenetic signatures through genome-wide DNA methylation profiling is crucial for cancer diagnostics and therapy.

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Last Updated: Jun 10, 2026

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer

Published on: September 18, 2020

Methyl-binding DNA capture Sequencing for Patient Tissues

Methyl-binding DNA capture Sequencing for Patient Tissues

Published on: October 31, 2016

Enhanced Reduced Representation Bisulfite Sequencing for Assessment of DNA Methylation at Base Pair Resolution

Enhanced Reduced Representation Bisulfite Sequencing for Assessment of DNA Methylation at Base Pair Resolution

Published on: February 24, 2015

Area of Science:

Genomics
Epigenetics
Oncology

Background:

Aberrant DNA methylation is prevalent in most cancers, contributing to malignant transformation by silencing tumor-suppressor genes.
Understanding tumor-specific DNA methylation signatures is vital for improved diagnostics and therapeutic strategies.

Purpose of the Study:

To review current key technologies for assessing genome-wide DNA methylation.
To discuss the implications of DNA methylation profiling in human cancers.

Main Methods:

Review of current high-throughput technologies for genome-wide DNA methylation analysis.
Discussion of epigenetic profiling techniques.

Main Results:

High-throughput technologies offer potent tools for epigenetic profiling.
DNA methylation profiling provides insights into tumor behavior.

Conclusions:

Efficient epigenetic profiling is essential, given the clinical use and trials of epigenetic therapies.
DNA methylation profiling holds significant potential for cancer diagnostics and treatment.