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Effect of testosterone therapy for delayed growth and puberty in boys with inflammatory bowel disease

A Mason1, S C Wong, P McGrogan

  • 1Developmental Endocrinology Research Group, University of Glasgow, Royal Hospital for Sick Children, Glasgow, UK.

Hormone Research in Paediatrics
|July 29, 2010
PubMed

Insights

Testosterone therapy effectively addresses pubertal delay and growth issues in boys with inflammatory bowel disease (IBD). Most patients experienced improved pubertal status and enhanced height velocity after treatment.

Area of Science:

  • Pediatric Endocrinology
  • Gastroenterology
  • Adolescent Medicine

Background:

  • Children with inflammatory bowel disease (IBD) frequently experience delayed puberty and growth retardation.
  • Understanding the impact of IBD on adolescent development is crucial for effective management.

Purpose of the Study:

  • To evaluate pubertal status and growth in boys with IBD receiving testosterone therapy for pubertal induction.
  • Assessing the efficacy of testosterone in mitigating IBD-related growth and pubertal delays.

Main Methods:

  • A retrospective analysis of 8 boys with IBD undergoing testosterone therapy.
  • Measurements included height, weight, and pubertal status before and after treatment.
  • Height velocity (HV) changes and disease activity markers were analyzed.

Main Results:

  • Seven out of eight boys showed an advancement in pubertal status.
  • Six boys experienced a significant increase in height velocity (HV) (p = 0.005).
  • Higher C-reactive protein levels correlated with lower HV during therapy (r = -0.786, p = 0.021).

Conclusions:

  • Testosterone therapy is generally associated with improved pubertal status in boys with IBD.
  • The treatment demonstrates a positive impact on growth, with significant increases in height velocity.
  • Monitoring disease activity is important, as it may influence treatment response.
Abstract

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